In CRC, stimulated by TNF-α, Granulocyte-macrophage colony-stimulating factor (GM-CSF), Platelet-activating factor (PAF), and CXCL8, neutrophils release CXCL8, CXCL1, and VEGF, inducing tumor angiogenesis (114). This evidence concerns the gene CXCL8 and neoplasm.