demonstrated that in CRC cells, CXCR4 upregulation mediates the transfer of specific miRNAs (miR-25-3p, miR-130b-3p, miR-425-5p) to macrophages via extracellular vesicles (EVs), thereby promoting M2 polarization through the PTEN/PI3K/Akt pathway (111). The gene discussed is AKT1; the disease is colorectal carcinoma.