The IL‐6/JAK/STAT3 activation also enhances metastasis ability of cancer cells via induction of EMT in gastrointestinal cancers by the upregulation of EMT‐inducing transcription factors such as EMT‐transcriptional factors, such as SNAIL, ZEB1, JUNB, and TWIST‐1 [198]. This evidence concerns the gene IL6 and cancer.