In hepatocellular carcinoma, CD49f also plays a prominent role in maintaining tumor‐initiating cells; CD49f‐high tumor‐initiating cells specifically recruit tumor‐promoting neutrophils via the CXCL2–CXCR2 axis and create an immunosuppressive milieu in the TME, thus sustaining tumor growth [126]. Here, CXCL2 is linked to neoplasm.