In 2013, Chiba and coworkers found that in APCmin mouse model of colorectal cancer, Dclk1+ tumor cells fulfilled all bona fide criteria of tumor stem cells continuously fueling adenoma growth and also expressed the known intestinal stem cell marker Lgr5, targeted depletion of Dclk1+ cells led to a significant regression of established adenoma [123]. Here, LGR5 is linked to colorectal cancer.