In return, TAMs support and expand CSC properties through multiple mechanisms, including the secretion of IL‐6, TGF‐β, MFG‐E8 and extracellular vesicles, direct cell–cell interactions, and remodeling of ECM, ultimately reinforcing cancer stemness and tumor malignancy [58, 64, 100]. Here, TGFB1 is linked to neoplasm.