In colorectal cancer, CD133+/CD24+ cells exhibit great clonogenic potential and multilineage differentiation, the expression of CD133 and CD24 also correlates with the expression of EGFR, KRAS, Ki67 as well as stemness‐related signaling pathways such as Wnt/β‐catenin and Hedgehog signaling pathways [127, 128]. Here, PROM1 is linked to colorectal cancer.