Environmental inflammatory factors such as TGF‐β1, chemokines, interleukin (IL)‐17, lipopolysaccharide, IL‐6, and HGF exist and play an important role in the regulation of non‐CSC acquired stemness or CSC maintenance stemness in the hepatic cancer cell tumor microenvironment (TME) [61, 62, 63, 64, 65]. The gene discussed is TGFB1; the disease is neoplasm.