Moreover, key signaling molecules involved in the processes of tumor occurrence, development, and metastasis (including PDGF, integrin, granulocyte‒macrophage colony‐stimulating factor [GM‐CSF], γ‐interferon and TGF‐β) can exert bidirectional regulatory effects on NOX‐dependent ROS production in tumor‐infiltrating immune cells. Here, TGFB1 is linked to neoplasm.