As detailed in Sections 2.2 (Hypoxia) and 3.2 (Angiogenesis), a self‐sustaining circuit exists between tumor hypoxia and angiogenesis: hypoxia induces HIF activation, which prompts the release of factors such as VEGF that stimulate aberrant neovascularization, resulting in the development of a leaky and tortuous vasculature and thereby further exacerbating hypoxia [137]. Here, VEGFA is linked to neoplasm.