CD8A and neoplasm: In the first tumorigenic stage, neutrophils show characteristics that predispose them to CD8+ T‐lymphocyte activation and the induction of tumor cell apoptosis through the production of ROS and different cytokines; nevertheless, elements such as TGF‐β or granulocyte colony‐stimulating factor (G‐CSF) can induce their phenotypic activation toward the immunosuppressive N2 type [87].