Lactic acid has long been considered a byproduct of cell metabolism in the TIME (cancer cells, stromal cells, and immune cells) [168], and new evidence suggests that lactic acid may be a metabolite in the TIME, promoting TAM polarization toward the M2 type in the microenvironment [169, 170] and the secretion of a variety of cytokines related to metabolic function, such as IL‐6, TNF, and CCL5, thereby directly or indirectly accelerating glycolysis in tumor cells [171]. This evidence concerns the gene TNF and neoplasm.