For example, in a hepatocellular carcinoma (HCC) murine model, M2 macrophage‐derived extracellular vesicles encapsulating miR‐21‐5p promoted CD8+ T‐cell exhaustion in the TIME by targeting YOD1 and activating the Yes‐associated protein (YAP)/β‐catenin pathway [101]. Here, YOD1 is linked to hepatocellular carcinoma.