SLC2A1 and central nervous system cancer: Several studies examining glutamate levels have reported conflicting data in relation to whether patients had a history of seizures or not pre-operatively.25,26,55 Metabolite differences between low-grade and high-grade gliomas are well established.56,57 We therefore also wanted to establish in our dataset whether there was any difference in Glut/Cre, NAA/Cre and Chol/Cre ratios across different patient groups.