BACE1 and Alzheimer disease: The findings reported a significant increase in the mRNA expression of Aβ precursor protein, APP (p = 0.0006 versus Control) and amyloidogenic protein, Bace1 (p = 0.0019 versus Control), followed by a significant rise in the enzymatic levels of neuronal amyloid-β protein (p = 0.0013 versus Control) in D-gal/AlCl3 induced AD-like amyloid neurotoxicity (Figures 4A–C).