Comorbidities, such as autoimmune diseases (ex.: systemic lupus erythematosus), as well as oral MHT can increase us-CRP.138 The use of statins (ex.: rosuvastatin) for patients with elevated us-CRP reduced cardiovascular events independently of LDL-c levels, as evidenced in the JUPITER study.137 Adjuvant strategies include diet and aerobic exercise that modulate inflammation, especially in postmenopausal women.139 Thus, us-CRP interpretation should be added to hormonal context, comorbidities, and lifestyle, guiding the treatment to mitigate CVR. This evidence concerns the gene CRP and systemic lupus erythematosus.