However, there is increasing evidence that it is a systemic chronic inflammatory disease associated with cardiovascular comorbidities, such as obesity, MS, and CVD, cerebrovascular diseases, cardiac arrhythmias, sleep apnea, etc. Although its pathophysiology has not been totally clarified, psoriasis’ systemic inflammation is believed to relate to a pro-inflammatory state with the participation of cytokines, such as TNF-α, IL-6, leptin, and other adipokines. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.