In individuals with T1DM or T2DM, the HbA1c goal of 6.5-7% should be pursued when estimated glomerular filtration rate >60 mL/min/1.73m2 and albumin/creatinine ratio >30 mg/g, to reduce the progression of albuminuria and DKD in the long run. The gene discussed is ALB; the disease is diabetic kidney disease.