INS and type 2 diabetes mellitus: If glycemia is not controlled in up to 14 days, pharmacological therapy should be initiated, and that is mandatory for pregnant women with pregestational T1DM or T2DM.202,205 In such cases, aspirin (100–150 mg/day) is recommended from the 12th-16th week on to prevent preeclampsia.192 Insulin is the drug of choice due to its efficacy, safety, and low placental transfer.192,195