The decrease in endogenous estradiol levels during menopause transition is associated with an increased risk of cardiometabolic disorders, such as abdominal adiposity, dyslipidemia, type 2 diabetes mellitus, and systemic arterial hypertension, which are related to renin-angiotensin-aldosterone system dysfunction, sympathetic activation, endothelial dysfunction, inflammation, and higher sodium sensitivity;. The gene discussed is REN; the disease is endothelial dysfunction.