REN and endothelial dysfunction: In addition, there are renin-angiotensin-aldosterone system dysregulation, sympathetic activation, endothelial dysfunction, inflammation, and higher sodium sensitivity.237,328 This leads to a rapid and accentuated increase in BP239 and high SAH prevalence in postmenopause, with consequent elevation in the risk of cardiovascular events, such as AMI, HFpEF, stroke, cognitive deficit, and peripheral artery disease, usually with systolic BP 10 mm Hg lower than in men.240 Moreover, women with SAH more frequently have CKD, left ventricular hypertrophy, and coronary microcirculation dysfunction.235