It is associated with a chronic inflammatory process mediated by substances, such as intercellular adhesion molecule, IL-1 and IL-6, TNF-α, and VEGF, which induce an increase in oxidative stress.181 A systematic review with 254,929 participants has revealed that the condition is associated with higher risk of IHD (HR 1.50) and cerebrovascular disease (HR 1.17).203. This evidence concerns the gene IL6 and cerebrovascular disorder.