GLP1R and diabetes mellitus: The American Diabetes Association recommends that women on oral contraception should choose a non-oral contraceptive method or add a barrier method of contraception during the first four weeks of tirzepatide use (GLP-1 analogue), because of its effects on gastric emptying, with potential consequences to the pharmacokinetics of oral contraceptives.292 Without implying sex-specific therapeutic recommendations, the following considerations are worthy of note: