After finding an association between the CARD14 R820W (rs11652075) variant and reduced epidermal FLG expression in children with AD (DeVore et al., 2021), our group noted prominently decreased MYC transcriptional signatures in keratinocytes with the variant despite only subtle decreases in NF-κB signaling (DeVore et al., 2024). This evidence concerns the gene CARD14 and Alzheimer disease.