Such studies would also help determine whether CARD11-MYC signaling could contribute to T-cell malignancies such as adult T-cell leukemia/lymphoma, which harbors CARD11 GoF mutations in about 25% of cases (Kataoka et al., 2015) and can demonstrate increased MYC activity (Kameda et al., 2022; Yamagishi et al., 2021). The gene discussed is MYC; the disease is lymphoma.