PIK3R3 and hematologic disorder: The significant influence of CARD11 signaling in lymphocytes is also demonstrated by its role in hematologic malignancies: GoF mutations and activating gene fusions (i.e., CARD11-PIK3R3) are associated with hematologic malignancies including B-cell and T-cell non-Hodgkin lymphomas (Ruland and Hartjes, 2019; Garcia et al., 2024).