It is associated with inflammatory skin diseases, including atopic dermatitis (AD), psoriasis vulgaris (PsV), and rarer psoriatic entities like generalized pustular psoriasis (GPP), pityriasis rubra pilaris (PRP), and CARD14-associated papulosquamous eruption (CAPE) (DeVore et al., 2024). This evidence concerns the gene CARD14 and familial pityriasis rubra pilaris.