EGFR and colorectal carcinoma: Future research should focus on: (1) optimizing dosing and imaging schedules to define the ideal clinical window for CRC; (2) validating EGFR-based stratification in larger PDX cohorts and clinical trials, and directly comparing EGFR-IRDye800CW with CEA-SGM-101; (3) integrating artificial intelligence-based algorithms to improve the objectivity and real-time interpretation of intraoperative imaging; and (4) conducting systematic pharmacokinetic, safety, and long-term oncologic outcome studies to support clinical translation.