Additional insights from the French POLA network suggest that age may influence prognosis at more advanced thresholds, reporting worse outcomes in patients over 70 years diagnosed with IDH-mutant grade 3 and 4 gliomas, the majority of whom had grade 3 IDH-mutant, 1p/19q-codeleted oligodendroglioma (91). The gene discussed is IDH1; the disease is glioma.