More recently, in a cohort of 111 IDH-wildtype glioblastoma patients (8) who underwent gross total resection (GTR) followed by standard Stupp protocol treatment (maximal safe surgical resection followed by radiation therapy and TMZ), MGMT methylation status was shown to be significantly associated with improved PFS and OS (Unmethylated: PFS 7.2 months, OS 13.4 months; Low methylation [10–20%]: PFS 10.4 months, OS 17.9 months; High methylation [>20%]: PFS 19.83 months, OS 29.93 months; p < 0.05). The gene discussed is IDH2; the disease is glioblastoma.