This review summarizes current insights into the role of BK<sub>Ca</sub> and mitoBK<sub>Ca</sub> channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BK<sub>Ca</sub>-directed therapies for glioblastoma treatment. The gene discussed is KNG1; the disease is glioblastoma.