STAT3 and hepatocellular carcinoma: We also confirmed that YAP overexpression could increase the STAT3 acetylation levels but not its phosphorylation levels in HepG2 cells, which was diminished when MAML1 was depleted by shRNA, strengthening the existence of YAP-MAML1-STAT3 axis in HCC cells (Supplementary Fig. 5E).