Cardona et al. [10], with similar inclusion criteria, noted fewer patients reporting angina (34.4% to 3.1%; p = 0.002), BNP reduction (323 to 123 pg/ml; p = 0.004), and better NYHA class at follow-up (72% to 100% in class I and II; p = 0.004). This evidence concerns the gene NPPB and angina pectoris.