Meanwhile, tumor cells can increase FAO levels by upregulating CPT1 expression, and high levels of FAO can promote EMT [100, 132, 133] and foster M2 macrophage polarization, which subsequently leads to the secretion of pro-inflammatory cytokines such as IL-1β, thereby augmenting tumor cell motility and proliferative capacity [134]. This evidence concerns the gene CPT2 and neoplasm.