Additionally, distinct lipid metabolic signatures are observed across diabetic complications: upregulation of FATP, FABP, CD36, and SREBP, together with downregulation of ATP-binding cassette transporter A1 (ABCA1) promotes renal lipid accumulation and injury in diabetic kidney disease; increased LDL and reduced ABCA1 impair cholesterol efflux in diabetic retinopathy; and sphingolipid levels are elevated despite unaltered LDL in diabetic peripheral neuropathy [163–165]. The gene discussed is ABCA1; the disease is diabetic kidney disease.