Immunoblot and β-gal staining found that MYH9 overexpression partially reversed KRT19 knockdown-induced p21 upregulation and β-gal accumulation (Fig. 7K-L), implying that MYH9-mediated p21 ubiquitination contributes to KRT19 deficiency-induced NSCLC cellular senescence. Here, CDKN1A is linked to non-small cell lung carcinoma.