GZMB and neoplasm: Flow cytometric analysis showed that Krt19 knockdown in LLC promoted IFN-γ and Granzyme B (GzMB) levels in tumor-infiltrating CTLs, indicating the in vivo importance of KRT19-mediated cellular senescence in TIME reprogramming, while intervention of Krt19 in NSCLC and anti-PD-1 could synergistically enhance the IFN-γ and GzMB production in intratumoral CTLs (Fig. 9G-I).