In hepatocellular carcinoma, KRT19 enhances the interaction of histone deacetylase 1 and REST corepressor 1 to increase the deacetylase activity of the corepressor of RE-1 silencing transcription factor (CoREST) complex, resulting in dedifferentiation and tumorigenesis [20]. Here, KRT19 is linked to hepatocellular carcinoma.