Mechanistically, KRT19 regulates cancer cell properties, especially the reprogramming of cancer stem cells by mediating β-catenin [59], glycogen synthase kinase-3 (GSK3β) [21] et al. In the study herein, we found that KRT19 overexpression significantly prevents cellular senescence and exhibits oncogenic activity in NSCLC via MYH9-dependent ubiquitination of p21 at K16, revealing an unconventional role of KRT19 in dictating tumor cell fate. The gene discussed is CDKN1A; the disease is cancer.