To gain insights into the mechanism underlying the connection between KRT19 and NSCLC cell senescence, we jointly analyzed RNA-seq data (GEO accession number: GSE298926) and CellAge database [45] and noticed that overexpression of KRT19 significantly inhibited the level of the cell cycle inhibitor p21, the well-known gene associated with cell senescence (Fig. 5A-B). The gene discussed is CDKN1A; the disease is non-small cell lung carcinoma.