Zong et al. discovered that alanyl-tRNA synthetase 1 (AARS1) mediated p53 lactylation at the K120 and K139 residues and hindered its liquid-liquid phase separation, DNA binding, and transcriptional activation of p21 [15], which is consistent with our notion that lactate is a natural inhibitor of the p53-p21 axis and senescence of tumor cells. This evidence concerns the gene CDKN1A and neoplasm.