KRT19 and colorectal cancer: KRT19 is abnormally expressed in various cancers including hepatocellular carcinoma [20], breast cancer [21, 22], colorectal cancer [23], papillary thyroid carcinoma [24], serous ovarian cystadenocarcinoma [25] and et al. KRT19 has been revealed to mediate cell cycle, cancer stem cell reprogramming by interacting with cellular molecules including receptors, adaptors, effectors and kinases.