Immunoblot and flow cytometric analysis showed that KRT19 knockdown could significantly downregulate proliferation-related CDK1, CDK6 and Cyclin D1 protein expression, which resulted in cell cycle arrest in G1 phase (Fig. 4D-E), supporting the notion that KRT19 knockdown induced cellular senescence of NSCLC. This evidence concerns the gene CCND1 and non-small cell lung carcinoma.