BRCA1 and brain cancer: These results indicate that in paediatric brain cancers (PBCA-DE) high methylation activity in the chromosome 1p36 region or in genes like HFM1 (average methylated read count = 1,448; average unmethylated read count= 2,493) might confer genome stability (e.g. through BRCA1 interaction)28 or may even suppress the formation of CNVs on chromosome 1.