Using neonatal C57BL/6 wild-type (WT) and GSDMD-knockout (GSDMD−/−) mice, we established a hyperoxia-induced BPD model (85% FiO2, 14 days) and administered the GSDMD inhibitor disulfiram (50 mg kg−1 intraperitoneally, once daily for 7 days). This evidence concerns the gene GSDMD and bronchopulmonary dysplasia.