HAO1 and neoplasm: In the mildly acidic tumor microenvironment, usAuNPs are expectedto induce tumor starvation by consuming glucose via GOx-like activitywhile simultaneously self-supplying H2O2 todrive •OH generation through POD-like activity.Concurrently, under ultrasound stimulation, usAuNPs generate toxic 1O2, which can synergistically amplify the overallanticancer effect of the treatment.