While recent studies have linked dsDNA-driven cGAS-STING signaling to AIM2 inflammasome activation in retinal ganglion cell death [32] and identified Lcn2-24p3R pathways in astrocytic pyroptosis after I/R8, the upstream regulators of AIM2 in astrocytes during cerebral ischemia-reperfusion remain poorly understood. The gene discussed is SLC22A17; the disease is brain ischemia.