In ischemic stroke, multiple inflammasomes (NLRC4, NLRP1, NLRP3, NLRP6, AIM2) have been implicated [31], with AIM2 uniquely recognizing cytosolic dsDNA to drive AIM2-ASC-caspase-1 complex formation [27] and GSDMD-mediated pyroptosis [28]. Here, AIM2 is linked to ischemic stroke.