Based on the above data, the objectives of the research were to perform an epidemiological analysis related to the presence of p16INK4a protein, in patients with HNSCC, to establish epidemiological, sociodemographic and clinical profile of these patients, and verify the association of the p16INK4a protein with survival time and recurrence. The gene discussed is CDKN2A; the disease is head and neck squamous cell carcinoma.