The overall survival and treatment also did not show significance with p16INK4a expression, however, it corroborates with the literature when concomitant chemoradiotherapy remains the treatment of choice for most patients with advanced HNSCC, while surgery remains the preferred modality for surgically respectable cancers of the oral cavity.34 The gene discussed is CDKN2A; the disease is head and neck squamous cell carcinoma.