The frequency of patients with HNSCC in all primary sites who died after the diagnosis of the disease with positive expression of the p16 INK4a protein were 30.1% of cases in total, with 44.0% cases of tumors in oropharynx and 24.1% cases of tumors in other anatomical sites, while 24.9% of patients was negative in total, with 23.1% cases of tumors in oropharynx and 25.6% cases of tumors in other anatomical sites, regardless of survival time. This evidence concerns the gene CDKN2A and head and neck squamous cell carcinoma.