Type 1 AIH (AIH-1) was characterized by antinuclear antibody (ANA) and/or smooth muscle antibody (SMA), whereas type 2 (AIH-2) was defined by anti-liver kidney microsomal type 1 (anti-LKM1) and/or anti-liver cytosol type 1 (anti-LC1) antibodies [59,60]. The gene discussed is SMN1; the disease is autoimmune hepatitis.