TNFSF4 and infection: Otero et al. deleted the gp34, gp68, and RL12 homologs from an RhCMV strain; subsequent infection of rhesus macaques showed accelerated viral control during primary infection that coincided with increases in anti-HCMV antibodies for animals infected with the vFcγR-deletion but not unmodified virus.26 Fc-engineered anti-HCMV antibodies could benefit transplant patients with impaired T cell function or congenitally infected infants whose outcomes depend on rapid virus control, but future studies are needed to define the clinical utility and scope of this approach.