Recently autoantibodies against CD74 have been linked to the pathogenesis of axSpA.<h4>Objectives</h4>Investigate the diagnostic value of anti-CD74 in Egyptian axSpA patients and their relation to disease activity.<h4>Methods</h4>This study included 30 axSpA patients and control groups, which included 30 patients with peripheral psoriatic arthritis, and 30 healthy volunteers. The gene discussed is CD74; the disease is psoriatic arthritis.