Although ENDOD1 has not been directly associated with stroke or ischemia, the established involvement of other endonuclease-related proteins (e.g., endonuclease VIII-like 1 and endonuclease G) in ischemic injury suggests a potential, yet unexplored, relevance in cerebral ischemia (Zhang et al. 2007; Canugovi et al. 2012). This evidence concerns the gene NEIL1 and brain ischemia.