MicroRNA-513b-5p downregulation in ruptured aneurysms (RA) and unruptured aneurysms (UA) targeted COL1A1 and COL1A2 genes, regulating RIP1-RIP3-MLKL and MMP pathways to enhance cell death and apoptosis.23 The gene discussed is COL1A2; the disease is aneurysm.