ESR1 and Dilatation of the cerebral artery: Finally, miRNA-based strategies remain of interest, as several dysregulated miRNAs (notably miR-126) have been linked to intracranial aneurysm pathophysiology and rupture risk, highlighting potential diagnostic and therapeutic applications.97 Moreover, a recent bioinformatics study by Lai et al.98 highlighted the potential involvement of estrogen receptor signaling (ESR1), suggesting that hormonal regulation may also contribute to IA pathophysiology and represent an additional therapeutic target.