The inverse correlation of high expression levels of STC1 and macrophage markers in the skin KS tumors, combined with previous reports of STC1 protein inhibiting macrophage chemotaxis, suggests a hypothetical model where KSHV infection of endothelial cells increases STC1 protein secretion and prevents macrophage chemotaxis to areas of KSHV infection in this model. The gene discussed is STC1; the disease is neoplasm.