While multiple genes that are trisomic in DS may be contributing to these changes, including App, Bace2, Bach1, and Sod1 (Barone et al., 2018; Head and Lott, 2004; Perluigi and Butterfield, 2012), Sod1 has been a focus of T21 studies related to oxidative stress due to its primary role in antioxidant defense. Here, APP is linked to Dravet syndrome.