Given the upregulation of the trisomic genes superoxide dismutase 1 (Sod1), amyloid beta precursor protein (App), and interferon (alpha and beta) receptor 1 or 2 (Ifnar1 or Ifnar2, respectively) in Dp16, Ts65Dn, and Ts66Yah, and the potential roles of these genes in human DS phenotypes (Barone et al., 2018; Galbraith et al., 2023; Lott et al., 2006; Malle and Bogunovic, 2021), we examined redox homeostasis, amyloid metabolism, and inflammatory factor status across all four mouse models. The gene discussed is APP; the disease is Dravet syndrome.