Increased APP levels in DS are associated with unbalanced proteolytic processing of APP that leads to a larger pool of Aβ fragments, aggregation of Aβ fragments, increased levels of amyloid beta (Aβ)-42, and increased production of reactive oxygen species (Barone et al., 2018; Butterfield et al., 2001; Head and Lott, 2004). Here, APP is linked to Dravet syndrome.