Supporting this mechanism, similar effects have been observed in NaV1.1‐deficient mice (Scn1a+/− mice; NaV1.1 encoded by Scn1a, Dravet syndrome models), where 5% CO2 reduced seizure duration and increased expression of the ASIC1a protein in the hippocampus [46]. The gene discussed is SCN1A; the disease is Dravet syndrome.