SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Supporting this mechanism, similar effects have been observed in NaV1.1‐deficient mice (Scn1a+/− mice; NaV1.1 encoded by Scn1a, Dravet syndrome models), where 5% CO2 reduced seizure duration and increased expression of the ASIC1a protein in the hippocampus [46].