The proteins unique to nonpapillary urothelial carcinoma (network B) were enriched in the PI3K-Akt signaling pathway (KEGG pathway, q=o.0040), with the most significant molecular function GO term being phosphatidylinositol-4,5-bisphosphate-3-kinase activity. The gene discussed is AKT1; the disease is urothelial carcinoma.