The proteins unique to the network specific to high-grade nonpapillary urothelial carcinoma included GNB1, UBC, FPR2, GNGT1, RHOA, PIK3CA, PIK3CG, PXN, UBE2N, SLC11A1, CCT7, HSP90AA1, and DOCK4. The gene discussed is PIK3CA; the disease is urothelial carcinoma.