The R177C mutation affects the prodomain of ADAM17 and causes cecum and central nervous system cancer, the D616N affects the membrane-proximal domain and causes cancer in colon and uterus, the D657A residue affects the membrane-proximal domain and causes colon cancer, and R725H residue affects the cytoplasmic domain and causes colon cancer [49]. The gene discussed is ADAM17; the disease is central nervous system cancer.