TP53 and colorectal carcinoma: Unlike traditional graphical user interface (GUI) tools, AI-HOPE-PM supports complex, user-defined queries such as “Analyze FOLFOX-treated colorectal cancer (CRC) patients with TP53 mutations and varying levels of financial strain.” The system autonomously identifies relevant data, filters patient cohorts, integrates clinical treatment and genomic mutation data with socioeconomic context, and generates statistical visualizations, survival curves, and interpretative summaries.