ANGPTL8 and polycystic ovary syndrome: Another study observed reduced betatrophin levels in patients with full-blown PCOS, particularly in those with a poor metabolic profile.(32) Unlike these studies, which often investigated a single BMI group or did not include BMI-matched controls, our study found that ANGPTL8 levels were significantly lower in both NW and SO PCOS groups compared to their NW and SO control counterparts.