Most research on ANGPTL3 has focused on conditions like type 2 diabetes and coronary artery disease.(35,36) It has been reported that ANGPTL3, 4, and 8 are elevated in obesity and type 2 diabetes(36) and that pharmacological inhibition of ANGPTL3 can reduce atherosclerotic lesion size.(35) Cinkajzlová et al.(37) found BMI to be an independent predictor of ANGPTL3 levels. The gene discussed is ANGPTL3; the disease is obesity due to melanocortin 4 receptor deficiency.