INS and metabolic syndrome: Circulating ANGPTL3 levels in PCOS patients were positively correlated with fasting glucose, fasting insulin, HOMA-IR, and triglycerides (TG), while showing a negative correlation with HDL, suggesting a potential direct link to dyslipidemia in PCOS patients.(16) While no significant correlations were found between ANGPTL3 and glucose or lipid parameters, levels were generally higher in the PCOS group compared to controls (210.11 ± 88.24 vs. 185.89 ± 67.59; p>0.05).