The results of multivariate logistic regression analysis indicated that age, hypertension, CRP, IL-6, TNF-α, serum albumin, prealbumin, Lp(a), and Hcy were significantly associated with myocardial injury in patients with advanced gastric cancer treated with fluorouracil and platinum-based chemotherapy (all p < 0.05). The gene discussed is TNF; the disease is hypertensive disorder.