The univariate and multivariate logistic regression analyses of the training set revealed that age, comorbid hypertension, CRP, IL-6, TNF-α, serum albumin, prealbumin, Lp(a), and Hcy were independent risk factors for myocardial injury in patients with advanced gastric cancer treated with fluorouracil combined with platinum-based chemotherapy. The gene discussed is TNF; the disease is hypertensive disorder.