1.High baseline CA-199(higher than normal vs. normal; p=0.03)2.High baseline CEA(higher than normal vs. normal; p=0.02)3.ECOG-PS >0 (ECOG 0 vs≧1; p<0.0001)4.Metastatic disease (vs. locally advanced; p=0.0001). This evidence concerns the gene CEACAM5 and metastatic neoplasm.