CLEC7A and candidiasis: In systemic candidiasis, recognition of fungal β-glucans by the C-type lectin receptor Dectin-1 (encoded by Clec7a) is pivotal for the activation of SYK–CARD9–NF-κB signaling, which induces pro-inflammatory cytokines such as TNF and IL-1β and promotes the generation of reactive oxygen species critical for fungal control (43, 44).