The effects of IL-17 release regulatory signals through two major pathways: firstly, by inducing the secretion of chemokines such as C-X-C motif chemokine ligand 1 (CXCL1) and C-X-C motif chemokine ligand 2 (CXCL2) to form chemotactic gradients that recruit neutrophils to infection sites (49, 50); secondly, by promoting the production of granulocyte colony-stimulating factor (G-CSF) to enhance neutrophil generation and activation(32). The gene discussed is CXCL2; the disease is infection.