CD8A and glioblastoma: In GBM, suppression of activating histone marks at CXCL9 and CXCL10 promoters limits CD8+ T-cell infiltration (15), while promoter demethylation of CCL2 enhances recruitment of monocytes and myeloid-derived suppressor cells (MDSCs), collectively skewing the TIME toward immunosuppression (63).