Recent multi-omic studies reveal that exhausted CD8+ T cells in glioblastoma share conserved chromatin architectures with those seen in chronic viral infection, including closed chromatin at effector genes (IFNG, PRF1, GZMB) and accessible enhancers near inhibitory-receptor loci (PDCD1, LAG3, HAVCR2). Here, IFNG is linked to glioblastoma.