In vitro, long noncoding RNA H19 (H19-IRP) promotes glioblastoma multiforme (GBM) immunosuppression by binding to CCL2 and galectin-9 promoters to activate its transcription and recruiting myeloid-derived suppressor cells (MDSCs) and TAMs to induce T cell exhaustion and an immunosuppressive GBM-TME. The gene discussed is CCL2; the disease is glioblastoma.