CCL2 directly promotes the proliferation, migration, and epithelial–mesenchymal transition of cancer cells by activating CCR2 receptor and its downstream PI3K/AKT, MAPK, and other signaling pathways and remodels the immunosuppressive microenvironment by recruiting tumor-associated macrophages and myeloid-derived suppressor cells. Here, AKT1 is linked to neoplasm.