MAPK3 and colorectal cancer: A recent investigation revealed that combined treatment with UA and Solasodine effectively suppressed the AKT1/ERK1/2-GSK-3β-β-catenin signaling pathway, thereby promoting apoptosis, autophagy, and exhibiting anti-metastatic properties through the inhibition of AKT1 and ERK1/2 (26).A study demonstrated that UA suppressed the proliferation of colorectal cancer (CRC) cells, affected the cell cycle, and enhanced apoptosis through the modulation of the miR-140-5p/TGF-β3 pathway.