GBA1 and Alzheimer disease: Recently, a stratified GWAS of DLB uncovered an association only between GBA rs2230288 and pathologically confirmed DLB without AD pathology, but not in mixed pathological cases.27 This same SNP has been identified as a significant risk variant in the most recent GWAS of DLB.7 It is possible that large-scale GWAS would uncover associations that encompass a broad spectrum of disease (e.g. DLB with no AD pathology, DLB with mixed PD and AD pathology, etc.), even though these associations may be driven by subsets of these genetic loci (e.g. GBA).