SNCA and multiple system atrophy: Alpha-synucleinopathy is an umbrella term to describe several neurodegenerative diseases that have a common defining pathological feature, characterized by neuronal or glial inclusions of aggregated alpha-synuclein, known as Lewy bodies, Lewy neurites or glial cytoplasmatic inclusions in the brain.1 Disorders that are collectively referred to as alpha-synucleinopathies include Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA).