Although the specific mechanism of FTMT in AD remains to be elucidated, this dual ability to regulate iron metabolism and mitigate oxidative stress explains the multidimensional phenomenon of the same receptor in a single cell, rather than a generalized enhancement of “overall mitophagy.” Overall, mitophagy receptors may regulate mitochondrial homeostasis and promote mitophagy in response to mitochondrial stress induced by Aβ and P-Tau via the non-PINK1-Parkin pathway. Here, MAPT is linked to Alzheimer disease.