MAPT and Alzheimer disease: The pathological hallmarks of AD include senile plaques (SPs) formed by extracellular amyloid-β protein (Aβ) deposition and accumulation of intracellular hyperphosphorylated microtubule-associated protein tau inclusions, resulting in neurofibrillary tangles (NFTs) that lead to synaptic degeneration, neuron loss, gliosis, and white matter pathology (89).