Huang et al., using an AKI mouse model established by cecal ligation and puncture (CLP) and an AKI cell model established by treating HK-2 cells with LPS, reported that Wtap knockdown promotes inflammation, ferroptosis, and cellular injury in LPS-treated HK-2 cells by upregulating lamin B1 (Lmnb1) expression while activating NF-κB and JAK2/STAT3 signaling pathways. Here, STAT3 is linked to acute kidney injury.