Ye et al. demonstrated through both mechanistic and clinical validation that in a murine model of sepsis, ALKBH5-mediated m6A demethylation stabilizes NF-κB inhibitor alpha (Nfkbia) mRNA, thereby elevating NFKBIA protein levels, suppressing p65 phosphorylation and nuclear translocation, inhibiting the NF-κB signaling pathway, and ultimately alleviating microglia-mediated neuroinflammation; furthermore, in human sepsis patient samples, ALKBH5 expression was found to correlate with disease severity. The gene discussed is NFKB1; the disease is Sepsis.