NLRP3 and Sepsis: Complementarily, Zhang reported that in a mouse model of sepsis, YTHDF1 can inhibit pyroptosis of cells and alleviate the damage caused by sepsis by promoting the ubiquitination of NLRP3 and upregulating the WW domain-containing E3 ubiquitin ligase 1 (Wwp1) (Zhang S. et al., 2022).