Pathways were considered significantly enriched if P value <0.05, therefore 8 pathways were identified for upregulated metabolites: thyroid hormone synthesis, serotonergic synapse, arachidonic acid metabolism, asthma, neuroactive ligand-receptor interaction, glutathione metabolism, Fc epsilon RI signaling pathway and synaptic vesicle cycle (Table 2). The gene discussed is TG; the disease is asthma.