Compared to other NSCLC subtypes, LUAD has been reported to have close associations with genomic variations, including TP53, KRAS, EGFR, NF1, BRAF, MET, and RIT mutations (7) that frequently occur and those rarely reported, such as HOXA4 and MST1 mutations (8). This evidence concerns the gene EGFR and non-small cell lung carcinoma.