The overexpression of CD206 has been associated with poor prognosis in locally advanced breast cancer (29), and in oral squamous cell carcinoma, it promotes tumor progression by releasing EGF and inhibits antitumor immune responses (30).Additionally, it is significantly correlated with tumor recurrence in mid-to-late stage colorectal cancer (31). This evidence concerns the gene MRC1 and oral cavity squamous cell carcinoma.