Fetuin-A increases coronary artery disease risk in individuals having T2DM but not in those without it [39,40], and a decreased risk of myocardial infarction is observed in women but not in men, highlighting potential gender-specific alterations in the pathophysiological role of fetuin-A in acute coronary syndrome [39,40]. The gene discussed is AHSG; the disease is type 2 diabetes mellitus.