SNCA and Alzheimer disease: In the past 2 decades, GWAS facilitated many discoveries, such as the identification of multiple novel risk loci in neurodegenerative diseases like AD and PD (CR1, BIN1, and PICALM for AD [93]; SNCA and MAPT for PD [94]) that elucidate roles in lipid processing, the immune system, and synaptic-cell functioning pathways.