Partial lipodystrophy syndromes are classified into Familial Partial Lipodystrophy (FPLD) including FPLD1 (Köbberling syndrome), FPLD2 (Dunnigan syndrome, due to mutations in the LMNA gene), FPLD3 (PPARG gene), FPLD4 (PLIN1 gene), FPLD5 (CIDEC gene), FPLD6 (LIPE gene) gene mutations. This evidence concerns the gene NOTCH3 and familial partial lipodystrophy.