AGPAT2 and generalized lipodystrophy: Congenital generalized lipodystrophy (CGL) includes different subtypes based on the different gene mutations involved such as AGPAT2, BSCL2, CAV1, PTRF, LMNA (e.g., T10I, biallelic lamin A specific variants), PPARG (biallelic variants), PCYT1A, PLAAT3 (2).