ERK1/2 is activated by FGL-1 to induce lipogenesis, and increased ERK1/2 phosphorylation stimulates C/EBPβ.FGL1 facilitates adipogenesisbyaERK1/2-C/EBPβ- dependent pathway, and targeting FGL-1 could be a novel therapeutic strategy in obesity and its related disorders (28). The gene discussed is FGL1; the disease is obesity due to melanocortin 4 receptor deficiency.