Our findings agree with those of Ahmad et al (56) who reported that eight weeks HIIT and MICT reduced PAI-1 levels women with T2D women, but with no difference between the HIIT and MICT groups likely because exercise of adaptation of skeletal muscles to the effects of PAI, including the gene expression and post-translational modifications (56). This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.