Next, three Cox regression models were conducted to adjust for potential confounders: Model 1: unadjusted; Model 2: adjusted for age, sex and race; Model 3 (AKI): adjusted for age, sex, race, BMI, ALT, glucose, creatinine and furosemide; Model 3 (Stage III AKI): adjusted for age, sex, race, BMI, creatinine, AST, bilirubin, hemoglobin, anion gap, hematocrit, albumin, lymphocytes, RRT, septic shock and SOFA score. The gene discussed is GPT; the disease is septic shock.