In genes related to DCM, the most frequent AAs were serine (e.g., SCN5A, MYH7), alanine (e.g., SCN5A, TNNT2), tyrosine (e.g., DSP, VCL), arginine (e.g., SCN5A, MYH7), and cysteine (e.g., MYH7, VCL). The gene discussed is SCN5A; the disease is familial dilated cardiomyopathy.