In addition, Ru­(II) polypyridyl complexes are well-knownfor their emissive properties and have been applied as fluorescenceimaging tags in various biological settings. The applicability of our Ru­(II) MT for targeted bimodal imagingof PARP1 was assessed in H446 xenograft tumor and mouse brain sections,via DESI-MSI and confocal fluorescence microscopy. Here, PARP1 is linked to neoplasm.